We propose a new hybrid data mining method for predicting protein-protein interactions combining Likelihood-Ratio with rule induction algorithms. In essence, the new method consists of using a rule induction algorithm to discover rules representing partitions of the data, and then the discovered rules are interpreted as “bins” which are used to compute likelihood ratios. This new method is applied to the prediction of protein-protein interactions in the Saccharomyces Cerevisiae genome, using predictive genomic features in an integrated scheme. The results show (...) that the new hybrid method outperforms a pure likelihood ratio based approach. (shrink)

Almost all existing genetic programming systems deal with fitness evaluation solely by testing. In this paper, by contrast, we present an original approach that combines genetic programming with Hoare logic with the aid of model checking and finite state automata, henceby proposing a brand new verification-focused formal genetic programming system that makes it possible to evolve reliable programs with mathematicallyverified properties.

In this paper we show that there are various pseudo-jump operators definable over inadmissible $J_{\beta}$ that relate to the failure of admissiblity and to non-regularity. We will use these ideas to construct some intermediate degrees.

If α is a singular cardinal (either real or fake) in L, I exhibit many natural α-re subsets, defined uniformly from the ▵ 1 subsets of α. If α is a true cardinal this provides an uppersemilattice (usl) embedding from the lattice of ▵ 1 subsets of α into the usl of α-re-degrees. It will also be shown that this embedding cannot be extended to the Σ 1 subsets of α.

If $\alpha$ is a singular cardinal (either real or fake) in $L$, I exhibit many natural $\alpha$-re subsets, defined uniformly from the $\triangle_1$ subsets of $\alpha$. If $\alpha$ is a true cardinal this provides an uppersemilattice (usl) embedding from the lattice of $\triangle_1$ subsets of $\alpha$ into the usl of $\alpha$-re-degrees. It will also be shown that this embedding cannot be extended to the $\Sigma_1$ subsets of $\alpha$.

The commentary argues that we cannot be sure that human consciousness has survival value and that in order to understand the origins and, perhaps, the function of consciousness, we should examine the behavioural and neural precursors to consciousness in nonhumans. An example is given of research on the role of context in decisions regarding fleeing from probable predators in the Mongolian gerbil.

As pressures on the service economy from globalisation increase, new techniques may be appropriate for designing service systems. This paper examines the tradition of service quality and argues that its unique characteristics, such as the joint production of offerings by operators and customers, could benefit from the techniques of human factors. The interaction between human factors and quality is reviewed and four issues are extracted that should be directly applicable to service encounters. These are interface design, the understanding of error (...) causation, a design for operator well-being and human/automation function allocation. A framework is proposed for considering technology explicitly in the design of service systems. (shrink)

The main function of vision in many animals is to control movement. In rodents, some visuomotor acts require the construction of models of the external world while others rely on Gibsonian invariants. Such findings support Norman's dual processing approach but it is not clear that the two types of processing rely on homologs of visual processing streams described in primates.

I consider the projectum of a \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $\beta$\end{document}-r.e. set. It is shown that there are tame r.e. sets with small projecta and that there are tame r.e. sets with large projecta.

Dreams represent threat, but appear to do so metaphorically more often than realistically. The metaphoric representation of threat allows it to be conceptualized in a manner that is constant across situations (as what is common to all threats begins to be understood and portrayed). This also means that response to threat can come to be represented in some way that works across situations. Conscious access to dream imagery, and subsequent social communication of that imagery, can facilitate this generalized adaptive process, (...) by allowing the communicative dreamer access to the problem solving resources of the community. [Revonsuo; Solms]. (shrink)

Cramer et al. articulate a novel perspective on comorbidity. However, their network models must be compared with more parsimonious latent variable models before conclusions can be drawn about network models as plausible accounts of comorbidity. Latent variable models have proven generative in studying psychopathology and its external correlates, and we doubt network models will prove as useful for psychopathology research.

Aristotelian philosophy played an important part in the history of 19th century philosophy and science but has been largely neglected by researchers. A key element in the newly emerging historiography of ancient philosophy, Aristotelian philosophy served at the same time as a corrective guide in a wide range of projects in philosophy. This volume examines both aspects of this reception history.

The idea that what is intrinsically good for people must be something they want or care about is a compelling one. Goal-fulfillment theories of well-being, which make this idea their central tenet, have a lot going for them. They offer a good explanation of why we tend to be motivated to pursue what’s good for us, and they seem to best explain how well-being is especially related to individual subjects. Yet such theories have been under attack recently for not being (...) able to account for robust or basic bads, such as pain and nausea. This paper argues that a psychologically informed goal-fulfillment theory can accommodate intuitions about robust bads by relying on aversions. Attending to aversion highlights a different sort of problem for goal-fulfillment theories, which comes from the possibility of a person who is so depressed that they have no goals or desires at all. We end the paper with a discussion of how empirically informed goal-fulfillment theories can account for the badness of the most serious form of depression. (shrink)

Charney's dismissal of well-established methods in behavioral genetic research is misguided. He claims that studies of heritability and genetic association depend for their validity on six assumptions, but he cites no sources to support this claim. We explain why none of the six assumptions is strictly necessary for the utility of either method of genetic analysis.

This chapter contains sections titled: Philosophers' fallacies and historians' fallacies Five Historical Fallacies Historical Fallacies of Philosophers and the Relationship of Philosophy to its History Bibliography Further Reading.

We demonstrate that Statistical significance (Chow 1996) includes straw man arguments against (1) effect size, (2) meta-analysis, and (3) Bayesianism. We agree with the author that in experimental designs, H0 “is the effect of chance influences on the data-collection procedure . . . it says nothing about the substantive hypothesis or its logical complement” (Chow 1996, p. 41).

The approach the majority of neuroscientists take to the question of how consciousness is generated, it is probably fair to say, is to ignore it. Although there are active research programs looking at correlates of consciousness, and explorations of informational properties of what might be relevant neural ensembles, the tacitly implied mechanism of consciousness in these approaches is that it somehow just happens. This reliance on a “magical emergence” of consciousness does not address the “objectively unreasonable” proposition that elements that (...) have no attributes or properties that can be said to relate to consciousness somehow aggregate to produce it. Neuroscience has furnished evidence that neurons are fundamental to consciousness; at the fine and gross scale, aspects of our conscious experience depend on specific patterns of neural activity – in some way, the connectivity of neurons computes the features of our experience. So how do we get from knowing that some specific configurations of cells produce consciousness to understanding why this would be the case? Behind the voltages and currents electrophysiologists measure is a staggeringly complex system of electromagnetic fields – these are the fundamental physics of neurons and glia in the brain. The brain is entirely made of electromagnetism phenomena from the level of the atoms up. The EM field literally manifests the computations, or signaling, or information processing/activities performed by connected cellular ensembles that generate a 1st-person perspective. An investigation into the EM field at the cellular scale provides the possibility of identifying the outward signs of a mechanism in fundamental terms, as opposed to merely describing the correlates of our mental abstractions of it. (shrink)

Corporate volunteering is known to be an effective employee engagement initiative. However, despite the prominence of corporate social responsibility in academia and practice, research is yet to investigate whether and how CV may influence consumer perceptions of CSR image and subsequent consumer behaviour. Data collected using an online survey in Australia show perceived familiarity with a company’s CV programme to positively impact CSR image and firm image, partially mediated by others-centred attributions. CSR image, in turn, strengthens affective and cognitive loyalty (...) as well as word-of-mouth. Further analysis reveals the moderating effect of perceived leveraging of the corporate volunteering programme, customer status and the value individuals place on CSR. The paper concludes with theoretical and managerial implications, as well as an agenda for future research. (shrink)

Adults are skilled at using language to construct/negotiate identity and to signal affiliation with others, but little is known about how these abilities develop in children. Clearly, children mirror statistical patterns in their local environment (e.g., Canadian children using zed instead of zee), but do they flexibly adapt their linguistic choices on the fly in response to the choices of different peers? To address this question, we examined the effect of group membership on 7‐ to 9‐year‐olds' labeling of objects in (...) a trivia game, exploring whether they were more likely to use a particular label (e.g., sofa vs. couch) if members of their “team” also used that label. In a preregistered study, children (N = 72) were assigned to a team (red or green) and were asked during experimental trials to answer questions—which had multiple possible answers (e.g., blackboard or chalkboard)—after hearing two teammates and two opponents respond to the same question. Results showed that children were significantly more likely to produce labels less commonly used by the community (i.e., dispreferred labels) when their teammates had produced those labels. Crucially, this effect was tied to group membership, and could not be explained by children simply repeating the most recently used label. These findings demonstrate how social processes (i.e., group membership) can guide linguistic variation in children. (shrink)

ABSTRACT Most American engineers believe that they have a responsibility for the safety and well‐being of society, but whence does this responsibility arise? What does it entail? After describing engineering practice in America as compared with the practice of other professions, this paper examines two standard types of accounts of the social responsibilities of professionals. While neither provides a satisfactory account of the social responsibilities of American engineers, several lessons are learned by uncovering their weaknesses. Identifying the framework in which (...) professional rights and responsibilities are justified, I argue that an end or primary good is the starting place for conceptualizing a profession, and justifying its existence and shape. Too little attention has been paid to the end(s) of engineering. The social responsibilities of American engineers as defined in the present system of engineering are ambiguous and weak. I indicate how the case for assigning American engineers stronger social responsibilities must be made by starting with the end(s) of engineering. I argue that, at present, American engineers do not have social responsibilities as engineers, though they do have social responsibilities as persons. (shrink)

Fitting the Mind to the World explores the brain's remarkable capacity to adapt to its current visual environment. Leading vision researchers explore how visual experience alters the adult brain, fitting the mind to the world, and ensuring the efficient coding of sensory signals. They demonstrate how this plasticity affects every aspect of our visual experience, from the perception of movement and colour, to the perception of subtle, social and emotional information in human faces.

From Socrates and the Sophists to Kant, from Augustine to Aquinas and the Reformers, Colin Brown traces the turbulent, often tension-filled, always fascinating story of the thinkers, ideas and movements that have shaped our intellectual landscape. Is philosophy the "handmaiden of faith" or "the doctrine of demons"? Does it clarify the faith or undermine the very heart of Christian belief?Brown writes, "This book is about the changes in preconceptions, world views and paradigms that have affected the ways in which (...) people have thought about religion in general and Christianity in particular in the Western world.... It is a historical sketch, written to help students--and anyone else who might be interested--to get a better grasp of the love-hate relationship between philosophy and faith that has gone on for close to two thousand years."Students, pastors and thoughtful Christians will benefit from this rich resource. The first in a proposed three-volume work, Brown's easy-to-read, hard-to-put-down introduction to Christianity and Western thought focuses on developments from the ancient world to the Age of Enlightenment. (shrink)